Carolee
J. Winstein, PH.D., P.T.,
FAPTA
Principal
Investigator: Carolee J. Winstein, Ph.D.,
PT, received her BA from the University
of California, Los Angeles (UCLA), her MS
from the University of Southern California
(USC), and her Ph.D., from the University
of California, Los Angeles. Prior to receiving
her Ph.D. Dr. Winstein served as Adjunct
Faculty at USC, Department of Physical Therapy
and Research Associate in the Department
of Kinesiology at UCLA. Following doctoral
training she was a postdoctoral fellow at
the University of Wisconsin in the area
of behavioral neuroscience. After postdoctoral
training she joined the faculty of USC and
was promoted to Associate Professor in 1996.
Her current primary academic appointment
is in the Department of Biokinesiology and
Physical Therapy where she is also Chair
of the Biokinesiology Program Committee,
the committee that administers the M.S.
and Ph.D. Programs in Biokinesiology. She
also holds joint appointments in the Department
of Neurology, Keck School of Medicine and
the Ph.D. Program in Neuroscience, within
the College of Letters, Arts and Sciences
of USC.
Dr. Winstein began her research career while
an undergraduate student enrolled in a combined
psychology-kinesiology major at UCLA. Ironically,
for her undergraduate thesis, she conducted
research in the laboratory of V.R. Edgerton,
Ph.D. (whose subsequent work with spinal
cats contributed significantly to the body-weight
supported treadmill training paradigm now
being tested in humans with spinal cord
injury) on the effects of exercise on rat
intrafusal muscle fibers. After training
to be a physical therapist, she again pursued
a Master’s degree part-time while
working as a clinician specializing in neurological
rehabilitation at Rancho Los Amigos Medical
Center (now Rancho Los Amigos National Rehabilitation
Center). Shortly after completing her M.S.
degree she pursued doctoral work with Richard
Schmidt, Ph.D. at UCLA in Kinesiology, specifically
in the areas of human motor control and
skill learning. Her postdoctoral fellowship
at the University of Wisconsin was in the
speech and motor control laboratory of James
Abbs, Ph.D. There, she initiated behavioral
studies in the neural control of grasp and
hand function. She has combined and continued
both lines of research using human models
in her laboratory at USC. Her current research
has direct clinical relevance to the recovery
of upper extremity function following central
nervous system damage (e.g., stroke). In
this regard, she recently completed an NIH
funded, phase II RCT, Recovery and Rehabilitation
of Arm Use Post-Stroke (Winstein et al.
2001). Since 2000, she has been the USC-Site
Principal Investigator for the NIH funded,
Multi-site Extremity Constraint-Induced
Therapy Evaluation (EXCITE) RCT in sub-acute
stroke (PI: Steven Wolf, Ph.D., P.T., FAPTA)
and, as of January, 2002 she became the
Co-PI for the multi-site EXCITE trial.
Dr. Winstein has taken an active leadership
role in promoting clinical research training
both at the program level and the policy
level within the APTA. She served as chair
of the research committee for the Neurology
Section of APTA from 1994-1996. She served
a three-year term as a member of the Postdoctoral
Fellowship and Doctoral Scholarship Committee,
for the Foundation for Physical Therapy
from 1995-1998. She received the Research
Award from the Neurology Section, APTA in
1998 and the Eugene Michels New Investigator
Award in 1992. She has been a member of
the Editorial Board of Physical Therapy,
the journal of the APTA since 1997. She
currently chairs the, Data Monitoring and
Safety Committee for the NIH funded clinical
trial,” Locomotor Therapy Trial for
Spinal Cord Injury” (NIH U01 HD37439,
PI: Bruce Dobkin, MD).
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