Researchers hope to use MRI for stroke treatment, recovery

Brain Scan


Stroke is the leading cause of disability in adults,affecting more than 15 million people worldwide each year, according to theWorld Health Organization. Researchers are increasingly using brain imaging toassess the damage caused by stroke and to predict how patients will recover. AUSC-led team has now compiled, archived and shared one of the largestopen-source datasets of brain scans from stroke patients via a study publishedFeb. 20 in Scientific Data, a Nature journal. 

The dataset, known as Anatomical Tracings of Lesion AfterStroke (ATLAS), is now available for download; researchers around the world already are using the scans to develop and test algorithms that can automatically process MRI images from stroke patients. Ultimately, scientists hope to identify biological markers that forecast which patients will respond to various rehabilitation therapies and personalize treatment plans accordingly.

During a stroke, blood flow to part of the brain is cut off.Without oxygen, brain cells die and cease to function. The damaged area, known as a lesion, is what researchers and clinicians study as they design, test and implement recovery programs. Typically, neuroanatomy experts manually draw boundaries around the lesions — in a process called segmentation — but researchers hope to automate this practice so they can examine more images. 

“One of our goals is to meta-analyze thousands of strokeMRIs from around the world to understand how the lesions impact recovery,” said Sook-Lei Liew, PhD, lead author of the study and assistant professor with joint appointments at the Keck School of Medicine of USC, the USC Chan Division ofOccupational Science and Occupational Therapy, the USC Division of Biokinesiology and Physical Therapy and the USC Viterbi School of Engineering.“We can’t do it by hand at the scale of thousands, so we are really interested in helping find better automated ways, using machine learning and computer vision, to identify the lesions and have machines draw those boundaries.”  

“Dr. Liew’s team is making great strides toward improving patient outcomes following stroke,” said Arthur W. Toga, PhD, Provost Professor of Ophthalmology, Neurology, Psychiatry and the Behavioral Sciences, Radiology and Engineering, Ghada Irani Chair in Neuroscience and director of the USC Mark and Mary Stevens Neuroimaging and Informatics Institute. “Several other faculty from the institute and across the university have applied their expertise in machine learning, data visualization, informatics and neuro radiology to deliver a valuable set of open-source MR images.” 

University-wide collaboration

The ATLAS team represents a truly collaborative effort both within USC and beyond. Hosung Kim, PhD, assistant professor of neurology at the Keck School, used a neuro imaging analysis pipeline he developed to help standardize the images in the dataset. Tyler Ard, PhD, assistant professor of research neurology at the Keck School, created custom software for advanced visualization of the lesioned dataset, rendering it into several extremely high-resolution videos and images. Seventeen other co-authors across the university assisted with analysis, clinical characterization, and the collection and storage of data. 

Data from the project are stored by the International Neuroimaging Data-Sharing Initiative (INDI), housed at the Child MindInstitute, and by the Inter-University Consortium for Political and SocialResearch (ICPSR), housed at the University of Michigan. So far, 33 research groups around the world, including from Finland, Iran and Australia, have downloaded the ATLAS dataset, which contains 304 manually-segmented MRI scans. 

Liew and Kim, along with PhD student Kaori Ito, have already started putting the dataset to work: they’re testing all of the existing algorithms that attempt to automate the lesion segmentation process to determine which perform the task with greatest accuracy. They presented their work at the annual meeting of the American Society for Neurorehabilitation inNovember and currently have a paper under review. 

Using MRI for treatment

As predictive algorithms improve, a long-term goal is for clinicians to use MRI to inform decisions about stroke patients’ treatment and recovery. 

“Ultimately, we would run their data through an automated pipeline that would give us some measures of their likelihood of recovery, or more importantly, their likelihood of responding to different types of therapies,” Liew said. “We could then personalize their rehabilitation therapy based on their MRI results and, hopefully, improve their recovery.” 

Stroke researchers who wish to access to data can download a normalized subset (n=229) from INDI or the full dataset (n=304) from ICPSR. 

This research was funded by the National Institutes ofHealth-funded Center for Large Data Research and Data Sharing in Rehabilitationunder a Category 2 Pilot Grant (P2CHD06570) and by a NIH K01 award from theNational Center for Medical Rehabilitation Research (K01HD091283). 


Posted 02.21.2018