DOSE Phase I Clinical Trial

3 line Division LogoThe USC Division of Biokinesiology and Physical Therapy is currently recruiting people with stroke who have upper extremity weakness for the Dose Optimization for Stroke Evaluation (DOSE) study.

DOSE is an NIH-funded (HD 065438), Phase I clinical trial in which 60 participants post-stroke with onset at least 6 months ago will be recruited. Enrolled participants are assigned to 1 of 4 groups to investigate the effectiveness of the dosage (in hours of therapy) of a rehabilitation intervention.

At 6 months post-stroke, individuals may no longer be receiving physical or occupational therapy. DOSE is a study for people who are experiencing residual weakness in an upper extremity or hand and are seeking options for more therapy. Eligible individuals:

• Are at least 21 years of age
• Are at least 6 months post-stroke
• Have paresis of the involved upper extremity
• Can voluntarily release a grasp
• Are medically stable
• Can attend evaluation and therapy sessions at the USC Health Science Campus

All screening and evaluations will be completed at the Center for Health Professions on the USC Health Sciences Campus. A stipend of $50 per evaluation is provided to the participants.

If you are interested in more details about the DOSE trial, please feel free to contact the study coordinator, Clarisa Martinez at, or by phone: 323-442-1410.